horiba raman application notes28 May horiba raman application notes
It has the advantage of being not only simple and inexpensive, but also allows for re-cycling used material. To utilize these subtle spectral changes and correlate them with physical properties of the polymer, one is obliged to use Chemometrics on the Raman spectra. Morphological and chemical characterizations of microplastic particles using ParticleFinder and Raman techniques. Different manufacturing technologies often result in products of very similar external appearance (from the visual and sensory points of view), but which differ completely in their micro/nanostructure. Photoluminescence emission and Raman response of monolayer MoS, Co-localized microscopy techniques for pyrite mineral spatial characterization, Study of geological materials with Raman Spectroscopy, Coloured diamond defect identification by Raman diffusion and photoluminescence. These include Fluorescence spectroscopy for photoactivity, Particle Size analysis for composition and Raman microscopy for formulation investigation. We have performed a complete Raman polarized study of a single GaN nanowire using a confocal microscope together with a high resolution stage. Raman Spectroscopy has many useful properties which can be explored and exploited in the analysis of pharmaceutical formulations. Laser diffraction and Raman microscopy were applied to highlight the benefits of combining two technologies for particle characterization. Rapid Polymer Identification of Fishing Gear Using Raman Spectroscopy. The first part of this note concerns the dispersion of the two components in a polyethylene-polybutylene terephthalate blend. In recent years, core-shell particles have attracted significant attention due to their smart properties. Optical Micro-spectroscopies on a Path to Identify the Source of Life. There are two types of vibrational modes in MoS2 (as in all layered structures): vibrational modes inside layers (intralayer) and modes resulting from the movements of complete layers (interlayer). Investigating the atherosclerosis process by monitoring lipid deposits including cholesterol and free fatty acids. Observing Oxidating Kinetics on an aluminium alloy surface with Fluorescence mapping. Development of methodology for Raman microspectroscopic analyis of oral exfoliated cells. We all consume or have all consumed sugary drinks at least once. Resulting from the combination of Raman spectroscopy and optical microscopy, Raman hyperspectral imaging has proven to be an indispensable tool in the pharmaceutical field. In the soap industry, many chemical reactions are involved for the preparation of the final product. As far as polymeric fibres are concerned, slight modifications of Raman features are directly related to differences in the molecular orientation and the degree of crystallinity of the fibres. Pharmaceutical and crystallographic samples typically require detailed characterisation and analysis to optimise a samples stability, physical properties and indeed general efficacy where an active drug substance is involved. Co-localized microscopy techniques for pyrite mineral spatial characterization. The ion-exchanged waveguides maintain the high nonlinear susceptibility of KTiOPO4 to function as frequency doubling laser light sources. Use the built-in filters to conveniently find the product or application of interest. Developed on the same platform, the LabRAM Odyssey is now more user friendly and offers new functionalities, advanced . Raman spectroscopic method for semen identification: azoospermia. With its non-destructive properties and high spatial resolution (< 1 m), Raman spectroscopy is thus a tool of choice for geological studies. Thus, Raman spectroscopy can be applied to large markets such as energy, environment, polymers and life sciences, to name a few. Use the built-in filters to conveniently find the product or application of interest. By coupling Raman spectroscopy with microscopy, it is possible to obtain full spectral information with a spatial resolution in the order of 1 m. Indeed, this system is the perfect combination between spatial resolution, spectral resolution and sensitivity, all integrated in an easy-to-use platform. The atmosphere contains a large variety of particles in suspension (aerosols) that differ in chemical composition as well as in size distribution depending on the region of the atmosphere, the meteorological conditions and the anthropogenic activity. Disinfecting your hands with hydroalcoholic gel has become a daily practice. Not only defects concentration but also local chirality changes from the different radial breathing modes, pressure effect and strain distribution can be studied at the single carbon nanotube level through TERS. The use of TERS to reveal the defects density in the structure of CNTs is of interest for a better understanding of the electrical properties of the devices made with such nano-objects. The application note explains how the Raman Spectroscopy can be helpful in the analysis of cathodes and anodes in Li-ion batteries. Identification of microplastics using Raman spectroscopy: Latest developments and future prospects. Hence, this allows the preservation of small traces of evidence for further analyses of the same specimen for confirmation of results. As it is highly chemically selective, it allows fast morphological and chemical characterization and identification of microparticles. Here, you can read the many application notes and articles created by HORIBA application scientists. Raman spectroscopy adapts to the different stages of life of these batteries, such as the characterisation of new materials for more flexible systems, failure analysis; but also more standard analysis of used material during charge/discharge process, including structural and electronic properties, and even robust, automated QC tests. In this application note, SERS is used to study the behaviour of glycoprotein IIb3 which plays a critical role in thrombosis (pathological blood clotting which can reduce or completely stop blood supply to tissues and organs, leading to myocardial infarction or stroke). The colour enhancement treatment on native brown and yellow diamonds can be highlighted by Photo Luminescence analyses performed with the Raman spectrometer LabRAM HR. Determination of extremely low concentration of sucrose in aqueous solution by Raman spectroscopy. Characterization of Carbon Nanotubes Using Tip-Enhanced Raman Spectroscopy (TERS). in this case, the inequivalent reaction rates of the two monomers. These differences in protective properties have therefore made it essential to characterize the composition of the masks. Spectroscopic Methods for Sunscreens Characterization. An imaging platform that combines Raman microscopy with enhanced darkfield and hyperspectral imaging technology was used to study lung tissue sections containing carbon nanotubes. It has been a problems for a long time for forensic scientists, customs officials and historians alike to be able to verify and authenticate printed documents just from the inks that have been used. Towards a spray-coating method for the detection of low-dose compounds in pharmaceutical tablets using surface-enhanced Raman chemical imaging (SER-CI). We have measured solutions of lysozyme under conditions known to effect its physical state in order to investigate the potential of Raman spectroscopy as a non-invasive and label-free tool to assess protein formulation stability. Raman Academy - Read - HORIBA Multimodal spectroscopy techniques for nanostructured materials characterization. It enabled easy identification of the regions containing the carbon nanotubes followed by spectroscopic characterization of chemical composition. 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Moreover the possibility of using both UV and visible excitation lines on the same instrument is essential to study structures made up of a Silicon cap layer on top of a SiGe layer. Natural rocks composing the Earth are complex. For hard carbon films, the spectra of amorphous and diamond-like carbons can be band-fit to separate the contributions of the "graphitic carbon" (G band) from the "disordered carbon" (D band). Using Chemometrics and Raman Spectra for Quantitative Predictions of Physical and Chemical Properties of Polymers. The objective of the measurements is to identify the unknown components and their respective dispersion within pharmaceutical tabs by Raman and FT-IR microspectrometry. The analyses revealed that the plate had an amorphous carbon coating on a titanium base plate. A grating is first inscribed with grooves along the X direction, the sample is rotated by 90 and a second grating is inscribed with grooves along the Y direction. As technology evolves at a high rate of speed, it requires more reliable, efficient and powerful energy sources. An automated Raman-based platform for the sorting of live cells by functional properties. Both TEPL and TERS images are well correlated with AFM morphological images obtained simultaneously, and all are consistent in revealing the nature (number of layers) of MoS2 flakes. Results from this study identified specific Raman signature bands in this protein that can be used to identify individual amino acid residues that are reflect structural changes in proteins. Due to Covid-19, a wide choice of protective masks are now on the market. Within biomedical research, its relevance to highly selective identification of biomolecules including amino acids and proteins, DNA/RNA and chemotherapeutic drugs is fast being realised. Consequently, all of the demonstrated potential of the spectroscopy for industrial uses can now be exploited, including its use in combination with statistical methods for concentration calibrations. Using the Raman technique, a sample is characterized in terms of chemical (actives and excipients identification, distribution and content), and physical (solid state/polymorphism, particle size) properties. Excipients and active pharmaceutical ingridients (APIs) can be analysed within seconds, and extensive Raman spectral libraries allow easy chemical identification. Raman Investigation of Micro-organisms on a single cell level. Raman Spectroscopy is a powerful and widely used analytical tool within the pharmaceutical industry. In addition, scientific expertise is mandatory for identification, dating and detection for falsification purposes. Natural rocks composing the Earth are complex. Raman spectroscopy can be applied to obtain information regarding the molecular composition of the skin down to several hundred micrometers below the skin surface. Number of layers of MoS2 determined using Raman spectroscopy, Graphene studies using Raman spectroscopy, SWNTs, Quality control by Raman spectroscopy. Raman and Resonance Raman Spectroscopy of Enzymes. " Tuschel D. (2019). Resulting from the combination of Raman spectroscopy and optical microscopy, Raman hyperspectral imaging has proven to be an indispensable tool in the pharmaceutical field, especially to study the distribution of active(s) and excipients in a pharmaceutical drug product. Ideally, we would like a technique that provides molecular information with resolution on a microscopic scale, that is non destructive of the samples, and can be set up and used on a laboratory bench top with a minimum of time and effort involved in sample preparation. Recent developments in Raman instrumentation have made the technique easier to use, more compact, and more affordable. Do you have any questions or requests? Localisation of Polymeric Phases by Raman Microscopy Mapping Components of a Blend in a Plane and Depth Profiles of Laminated Film. Prof. Philippe Colomban, CNRS Research Professor Emeritus, Sorbonne University, France, gives an insight into his research in the field of material science and the use of Raman spectroscopy to gain a greater understanding of ancient Chinese artefacts. For the study of a pharmaceutical drug product, particle characteristics (count, size and chemistry) and compound distributions (size and spatial) are among key parameters that strongly determine the quality of the product due to their huge impact on the dissolution rate (and thus bioavailability) for the final solid dosage form. Its non-invasive behavior, and its high molecular sensitivity make it one of the preferred label-free analytical techniques to characterize materials such as skin and cosmetic products. Back to Particle Characterization Products OverviewBack to Download Center, Laser Scattering Particle Size Distribution Analyzer, Simultaneous Multi-Laser Nanoparticle Tracking Analysis (NTA), Static Image Analysis System Particle Size. Recycling of damaged or abandoned fishing gear is one way of mitigating the issue, however the exact nature of the polymer must be known in order to identify the correct recycling stream. Characterization of MoS2 Flakes using TEOS. They consist of an aggregate of one or more minerals. application notes and articles, and get new perspectives on your lab research. The spectral behaviour of carbon films has been empirically correlated with thin film physical properties such as hardness, durability, optical transparency, electrical conductivity, thermal conductivity and corrosion resistance, and can be of use for prediction of these properties without extensive alternative testing. When exposed to warm and humid weather over time, ingredients may undergo change in their hydration level, thus affecting the properties and/or efficiency of the drug. Spectroscopy, 34 (3):10-21 In addition, only minima quantities of material are required thanks to the high spatial resolution of the confocal system. Raman microprobe spectroscopy is an ideal candidate for this type of studies. The main goals of analytical techniques in this domain are the determination of composition via quantitative methods, quality control (including adulteration, bacterial contamination), and identification of impurities or undesired material. Here, we use Raman microscopy by cross-section analysis and confocal depth profiling to investigate the chemical composition of two multilayers films. Various materials and surface treatments have been developed to improve their properties. However, the efficiency of Raman scattering is low, and collection times can be long, and detection limits high. By coupling this technique with the Raman spectroscopy z-Scan analysis it is possible to acquire important information concerning the fabrication of smartphone screen protectors. Particle Analysis Application Notes Products Particle Characterization Application Notes Back to Particle Characterization Products Overview Back to Download Center Particle Analysis Application Notes Calcium Carbonate Particle Sizing for Paint and Coating Applications | LA-960V2 Cold gas spray titanium coatings onto a biocompatible polymer. HORIBA offers all the tools necessary to analyze and characterize the presence of Microplastics in hand sanitizers: High-performance Raman microscopes, dedicated filtration kit, and especially the powerful particles detection software ParticleFinder. Correlated TERS, TEPL and SPM Measurements of 2D Materials. Its been more than a decade that Raman spectroscopy has been recognized as an efficient and powerful analytical tool in the field of Forensic Science. Derivation of Physical Parameters from Raman Spectra of Hard Carbon Films. Raman spectroscopic analysis of geological and biogeological specimens of relevance to the ExoMars mission. They often play an important role in electronic, material or biological applications; Quasi-2D structures, such as heterostructures, comprised of a stack of very thin layers, thus exhibiting new physical properties; 1D materials which include carbon nanotubes, nanowires, and nanorods; and. Micro-machining, thin layers ablation, two-photon polymerization are just a few examples of what has already been demonstrated. Graphene is a new nanomaterial which may partially replace silicon in microcircuits and computer chips in the future. Single-Walled Carbon Nanotube (SWNT) Quality Control by Raman Spectroscopy. Vibrational spectroscopic characterization can take place all along the catalyst life from the control of the synthesis of the precursor to the cpntrol of the catalyst regeneration via the analysis of the surface reaction mechanism. In a quiet NYC neighborhood, a frustrated artist created forgeries of Americas Modernistic masters. Particle Analysis Application Notes - Horiba Archaeometric analysis of ancient pottery. Raman spectroscopy, combined to a temperature and humidity controller can mimic such harsh conditions and can be used to monitor the properties of the different ingre-dients and track their modifications induced by environmental changes. Combined Raman and Photoluminescence Imaging of 2D WS2. Simultaneous acquisition of photoluminescence spectra with the Raman scattering provides complementary ways of rendering Raman and photoluminescence spectral images of thin film WS2. Blending, an alternative method for engineering products that combines the properties of polymer types is a physical mixing. Polarized Raman analysis of polymer chain orientation in ultrafine individual nanofibers with variable low cristallinity. Transmission Raman Spectroscopy: review of applications. Characterization and mapping of active pharmaceutical ingredients and excipients in a tablet using Raman and IR spectroscopy. Transmission Raman spectroscopy: review of applications, Concentration profile measurements in polymeric coatings during drying by means of Inverse-Micro-Raman-Spectroscopy (IMRS), Raman imaging of holographic gratings inscribed on polymer thin films. One of the major challenges in the pharmaceutical development of a new product consists in its formulation, highly impacting the release and the efficiency of the active molecules in the body. Study of geological materials with Raman Spectroscopy. The natural scientific identification of pigments has some problems because of their insolubility in common solvents. Thus, in this application note, the identification and chemical characterization of aeroallergens by Raman microscopy will allow to prevent people who are affected by respiratory allergies of the presence of this type of allergens in indoor and outdoor air. The Raman effect is highly sensitive to slight differences in chemical composition and crystallographic structure. In vitro monitoring of time and dose dependent cytotoxicity of aminated nanoparticles using Raman spectroscopy. In order to better understand its quality characteristics, fast reliable techniques that deliver the right property measures are needed.
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