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N.Engl J Med 8-10-1978;299(6):285-289. Hwang SY, Ryoo SM, Park JE, et al. Palestine, M. L. and Alatorre, E. Control of acute alcoholic withdrawal symptoms: a comparative study of haloperidol and chlordiazepoxide. Scientists are studying thiamin to better understand how it affects health. Vopr.Med Khim. The Combination treatment of arsenic trioxide and Alltrans-retinoic acid in patients with acute promyelocytic leukemia. View abstract. B., Sole, M., Anker, S. D., Cleland, J., Fonarow, G. C., Metra, M., Pasini, E., Strzelczyk, T., Taegtmeyer, H., and Gheorghiade, M. Micronutrient deficiencies an unmet need in heart failure. Christiansen, C., Rodbro, P., and Lund, M. Incidence of anticonvulsant osteomalacia and effect of vitamin D: controlled therapeutic trial. Hart, W. T. A comparison of promazine and paraldehyde in 175 cases of alcohol withdrawal. OTHER NAME(S): Aneurine Hydrochloride, Antiberiberi Factor, Antib. Beriberi is not common in the United States and other developed countries. Nutr Clin Pract 2009;24(1):60-75. 2019;38(3):1269-1273. Cochrane Database Syst Rev 2006;(4):CD001880. Eur J Clin Pharmacol. Clin Pharmacol Ther 1977;21(4):497-514. B-complex vitamins are needed for a healthy liver . J Am Diet Assoc 1980;76:581-4.. View abstract. View abstract. Tallaksen, C. M., Sande, A., Bohmer, T., Bell, H., and Karlsen, J. Kinetics of thiamin and thiamin phosphate esters in human blood, plasma and urine after 50 mg intravenously or orally. Chest. Effect of oral contraceptive agents on vitamin and mineral requirements. Wahed, M., Geoghegan, M., and Powell-Tuck, J. Finkle, B. S., McCloskey, K. L., and Goodman, L. S. Diazepam and drug-associated deaths. Macias-Matos, C., Rodriguez-Ojea, A., Chi, N., Jimenez, S., Zulueta, D., and Bates, C. J. Biochemical evidence of thiamine depletion during the Cuban neuropathy epidemic, 1992-1993. Water-soluble vitamins in milk and milk products. 2010;19(6):527-533. A phase I trial of naloxone treatment in acute spinal cord injury. Cardiology 1999;91(2):92-95. Overview Thiamine (vitamin B1) is found in many foods and is used to treat low thiamine, beriberi, certain nerve diseases, and Wernicke-Korsakoff syndrome (WKS). Thiamine fortification strategies in low and middleincome settings: a It is also involved in the flow of electrolytes into and out of . Am J Psychiatry 1973;130(12):1381-1382. Curr Mol.Med 2001;1(2):197-207. Alcohol Clin Exp Res 1989;13(3):361-364. Results of a randomized clinical trial. Q.J Stud.Alcohol 1965;26:10-18. A deficiency of thiamine, or vitamin B1, may go undiagnosed and is associated with poor health outcomes, including death. 2020;9(1):30-35. Thiamine (vitamin B1) is found in many foods and is used to treat low thiamine. Thiamin - Consumer - Office of Dietary Supplements (ODS) [Vitamin disturbances in chronic renal insufficiency. Curr Diabetes Rev 2005;1(3):287-298. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. BMC Anesthesiol. View abstract. View abstract. Shimon I, Almog S, Vered Z, et al. View abstract. Thiamine mononitrate is also known as vitamin B1 nitrate and has the molecular formula C 12 H 17 N 5 O 4 S. The molar mass of this compound is about 327.36 g/mol. 11-1-1980;2(9):504-506. Am J Clin Nutr 1975;28(12):1458-1463. View abstract. Am J Hematol 1999;61:155-6. View abstract. View abstract. Nutr.Cancer 2000;36(2):150-154. Z., Khoury, A., Schwartz, Y., and Mandel, H. Cardiac manifestations in thiamine-responsive megaloblastic anemia syndrome. View abstract. View abstract. View abstract. Ryoikibetsu.Shokogun.Shirizu. What is Thiamine Mononitrate What is Thiamine Mononitrate: Uses, Warnings & Interactions Thiamine Mononitrate Overview BRAND NAMES: Optimum Vitamin B-1, Sundown Naturals B1, Sundown Naturals B1, Vitamin B1 AvPak, Sundown Naturals B1 Generic Names: Thiamine Mononitrate Uses: What kinds of thiamin dietary supplements are available? Cochrane Database.Syst.Rev 2000;(2):CD001498. Endocrinol Metab Clin North Am 1993;22(2):209-219. 2009;24(1):1-9. Arch Neurol. Martin, P. R., McCool, B. Associations between early thiamine administration and clinical outcomes in critically ill patients with acute kidney injury. Thiamine is used to treat beriberi (tingling and numbness in feet and hands, muscle loss, and poor reflexes caused by a lack of thiamine in the diet) and to treat and prevent Wernicke-Korsakoff syndrome (tingling and numbness in hands and feet, memory loss, confusion caused by a lack of thiamine in the diet). Nippon Rinsho 2005;63 Suppl 6:244-249. Reducing symptoms of PMS - High doses (100 mg daily) of thiamine mononitrate can dramatically decrease the symptoms of premenstrual syndrome (PMS), such as hot flushes, anxiety, cramps, bloating, acne, headaches, and mood swings. B vitamin status and concentrations of homocysteine and methylmalonic acid in elderly German women. Gurll, N. J., Reynolds, D. G., Vargish, T., and Lechner, R. Naloxone without transfusion prolongs survival and enhances cardiovascular function in hypovolemic shock. McEntee, W. J. Wernicke's encephalopathy: an excitotoxicity hypothesis. A comparison of three approaches to alcohol-withdrawal states. Diet and premalignant lesions of the cervix: evidence of a protective role for folate, riboflavin, thiamin, and vitamin B12. View abstract. J Stud.Alcohol 1977;38(11):2096-2108. Thiamine deficiency in a patient receiving chemotherapy for acute myeloblastic leukemia (letter). Thiamine hydrochloride injection package insert. This fact sheet by the National Institutes of Health (NIH) Office of Dietary Supplements (ODS) provides information that should not take the place of medical advice. ECKENHOFF, J. E. and OECH, S. R. The effects of narcotics and antagonists upon respiration and circulation in man. 2017 Jun;151(6):1229-1238. Avenell, A. and Handoll, H. H. Nutritional supplementation for hip fracture aftercare in the elderly. Thiamine, cobalamin, locally injected alone or combination for herpetic itching: a single-center randomized controlled trial. 2007;(4):CD005414. Gallimberti L, Canton G, Gentile N, et al. View abstract. Acute Wernickes encephalopathy precipitated by glucose loading. Monogr Gesamtgeb.Psychiatr.Psychiatry Ser. View abstract. Information from this source is evidence-based and objective, and without commercial influence. B. Advanced glycation endproducts: what is their relevance to diabetic complications? View abstract. Int J Crit Illn Inj Sci 2021;11(2):86-94. Wallis, W. E., Donaldson, I., Scott, R. S., and Wilson, J. Hypoglycemia masquerading as cerebrovascular disease (hypoglycemic hemiplegia). View abstract. Benfotiamine: Uses, Benefits, Side Effects, Dosage - Verywell Health Arora, S., Lidor, A., Abularrage, C. J., Weiswasser, J. M., Nylen, E., Kellicut, D., and Sidawy, A. N. Thiamine (vitamin B1) improves endothelium-dependent vasodilatation in the presence of hyperglycemia. Cochrane Database Syst Rev 2004;(1):CD001880. Acta Psychiatr.Scand Suppl 1986;327:144-148. What Is Thiamine and How Does It Work? J Allergy 1941;12:507-509. 1996;103:227-231. Eur J Gastroenterol.Hepatol. J Mol.Med 2004;82(8):510-529.

View abstract. Dextrose: Administration of dextrose may precipitate acute symptoms of thiamine deficiency; use caution when thiamine status is marginal or suspect. J.Thromb.Thrombolysis. View abstract. View abstract. Saif MW. Biological functions Thiamine monophosphate (ThMP) Five natural thiamine phosphate derivatives are known: thiamine monophosphate (ThMP), thiamine pyrophosphate (TPP), thiamine triphosphate (ThTP), adenosine thiamine diphosphate (AThDP) and adenosine thiamine triphosphate (AThTP). A. Hazell, A. S., Todd, K. G., and Butterworth, R. F. Mechanisms of neuronal cell death in Wernicke's encephalopathy. View abstract. View abstract. Brain Behav Immun Health 2021;14:100252. Some medicines can lower thiamin levels in the body. View abstract. JAMA 2020 Jan 17. doi: 10.1001/jama.2019.22176. Int J Vit Nutr Res 1979;49:291-5. View abstract. 1988;

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Esperanza-Salazar-De-Roldan, M. and Ruiz-Castro, S. Primary dysmenorrhea treatment with ibuprofen and vitamin E. Revista de Obstetricia y Ginecologia de Venezuela 1993;53(1):35-37.

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Fontana-Klaiber, H. and Hogg, B. Cascante, M., Centelles, J. J., Veech, R. L., Lee, W. N., and Boros, L. G. Role of thiamin (vitamin B-1) and transketolase in tumor cell proliferation. For more in-depth information, see our health professional fact sheet on Thiamin. 1988;45(8):833-835. View abstract. [1] Only small amounts are stored in the liver, so a daily intake of thiamin-rich foods is needed. It's found in many foods, including cereal grains, beans, nuts, and meat. Oncol Rep. 2005;14(6):1589-1592. Med Toxicol Adverse Drug Exp 1988;3(3):172-196. Pulsinelli, W. A., Waldman, S., Rawlinson, D., and Plum, F. Moderate hyperglycemia augments ischemic brain damage: a neuropathologic study in the rat. [Development of therapeutic agents for diabetic neuropathies]. Ralston, A. J., Snaith, R. P., and Hinley, J. Grant, R. H. and Stores, O. P. Folic acid in folate-deficient patients with epilepsy. Avenell, A. and Handoll, H. H. Nutritional supplementation for hip fracture aftercare in older people. Thiamine mononitrate is also known as Vitamin B1. Does metformin interfere with thiamine?--Reply.

Avsar, A. F., Ozmen, S., and Soylemez, F. Vitamin B1 and B6 substitution in pregnancy for leg cramps. View abstract. Effects of Oral Vitamin B1 and Mecobalamin on Dry Eye Disease. Bonnet, F., Bilaine, J., Lhoste, F., Mankikian, B., Kerdelhue, B., and Rapin, M. Naloxone therapy of human septic shock. View abstract. Bulging fontanelle after supplementation with 25,000 IU of vitamin A in infancy using immunization contacts. Thiamine Dosage Guide + Max Dose, Adjustments - Drugs.com Allwood, M. C. and Kearney, M. C. Compatibility and stability of additives in parenteral nutrition admixtures. LATIES, V. G., LASAGNA, L., GROSS, G. M., HITCHMAN, I. L., and FLORES, J. View abstract. Nippon Rinsho 2002;60 Suppl 4:670-673.

View abstract. Lomivorotov VV, Moroz G, Ismoilov S, et al. View abstract. View abstract. The administration of folic acid to institutionalized epileptic adults with phenytoin-induced gingival hyperplasia. It causes tingling and numbness in the hands and feet, severe memory loss, disorientation, and confusion.

Ristow, M. Neurodegenerative disorders associated with diabetes mellitus. Kaim, S. C., Klett, C. J., and Rothfeld, B. View abstract. Ann Neurol. Ann Intern Med 1976;84(4):426-432. View abstract. View abstract. Leslie D, Gheorghiade M. Is there a role for thiamine supplementation in the management of heart failure? Mezadri, T., Fernandez-Pachon, M. S., Villano, D., Garcia-Parrilla, M. C., and Troncoso, A. M. [The acerola fruit: composition, productive characteristics and economic importance]. View abstract. Alertonic, Concept Ob, Fortaplex, Infuvite, Infuvite Pediatric, Irospan 24/6 Kit, Mvc-fluoride, Mvi Pediatric, Natafort, Neo-bex, Pregvit, Tandem Plus, Vitafol-one . VICTOR, M. and ADAMS, R. D. The effect of alcohol on the nervous system. Manore, M. M. Effect of physical activity on thiamine, riboflavin, and vitamin B-6 requirements. A controlled therapeutic trial. Thiamin - Vitamin B1 - Harvard T.H. Chan School of Public Health Thiamine nitrate | C12H17N5O4S | CID 10762 - PubChem Hum Exp Toxicol 1996;15(6):482-488. View abstract. Thereafter, use an oral therapeutic multivitamin preparation containing 5 to 10 mg thiamine daily for one month. Schweizerische Rundschau fur Medizin Praxis 1990;79(16):491-494.

. DATES: This regulation is effective November 5, 2020. Avenell, A. and Handoll, H. H. Nutritional supplementation for hip fracture aftercare in the elderly. Groeger, J. S., Carlon, G. C., and Howland, W. S. Naloxone in septic shock. Long-term maintenance treatment with 300 mg thiamine for fatigue in patients with inflammatory bowel disease: results from an open-label extension of the TARIF study. History of changes to this fact sheet, U.S. Department of Health & Human Services, Division of Program Coordination, Planning, and Strategic Initiatives, Strengthening Knowledge and Understanding of Dietary Supplements, My Dietary Supplement and Medicine Record, Analytical Methods and Reference Materials (AMRM), NIH Consortium for Advancing Research on Botanical and Other Natural Products (CARBON) Program, Computer Access to Research on Dietary Supplements (CARDS) Database, Dietary Supplement Ingredient Database (DSID), ODS Participation in NIH Funding Initiatives, Administrative Supplements for Research on Dietary Supplements, Administrative Supplements for Validation Studies of Analytical Methods, Frequently Asked Questions About ODS Grants & Co-funding, Resources for Investigators Submitting Natural Products Research Grant Applications, Staff Bios, Publications, and Presentations, Federal Working Group on Dietary Supplements, NIH Dietary Supplement Research Coordinating Committee. Chuang, D. T., Chuang, J. L., and Wynn, R. M. Lessons from genetic disorders of branched-chain amino acid metabolism. Pfitzenmeyer P, Guilland JC, d'Athis P, et al. Sellers, E. M., Zilm, D. H., and Degani, N. C. Comparative efficacy of propranolol and chlordiazepoxide in alcohol withdrawal. Rogovik, A. L., Vohra, S., and Goldman, R. D. Safety considerations and potential interactions of vitamins: should vitamins be considered drugs? Foy, A., March, S., and Drinkwater, V. Use of an objective clinical scale in the assessment and management of alcohol withdrawal in a large general hospital. Water soluble vitamins]. Am I getting enough thiamin? Minimal sedation required with nitrous oxide-oxygen treatment of the alcohol withdrawal state. Thiamine taken by mouth (oral . The amount of thiamin you need depends on your age and sex. View abstract. View abstract. 2002;39(4):270-281.

View abstract. Zayed Y, Alzghoul BN, Banifadel M, et al. This form of vitamin B is known as 'aneurin' in Europe and the UK. Supplements containing B-complex vitamins (including thiamin) or thiamin only are also available. Kramp, P. and Rafaelsen, O. J. Delirium tremens: a double-blind comparison of diazepam and barbital treatment. Stojek, A. and Napierala, K. Physostigmine in eyedrops decreases craving for alcohol in early withdrawal treated with carbamazepine. View abstract. View abstract. View abstract. Day E, Bentham P, Callaghan R, et al. Improved left ventricular function after thiamine supplementation in patients with congestive heart failure receiving long-term furosemide therapy. Sumner, A. D. and Simons, R. J. Delirium in the hospitalized elderly. View abstract. View abstract. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. Poppell, T. D., Keeling, S. D., Collins, J. F., and Hassell, T. M. Effect of folic acid on recurrence of phenytoin-induced gingival overgrowth following gingivectomy. Begley, T. P. The biosynthesis and degradation of thiamin (vitamin B1). It is often used in combination with other B vitamins. Suzuki, S. [Role of mitochondrial dysfunction in pathogenesis of diabetic microangiopathy]. We currently have no information for THIAMINE (VITAMIN B1) overview. 2013 Oct;52(7):1821-4. View abstract. Scand J Gastroenterol 2022;57(1):37-43. 1993;44(1):73-78. Baines, M., Bligh, J. G., and Madden, J. S. Tissue thiamin levels of hospitalised alcoholics before and after oral or parenteral vitamins. Flacke, J. W., Flacke, W. E., and Williams, G. D. Acute pulmonary edema following naloxone reversal of high-dose morphine anesthesia. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. Babaei-Jadidi R, Karachalias N, Ahmed N, et al. Indian J Pediatr 2009;76(3):313-314.

View abstract. Roje, S. Vitamin B biosynthesis in plants. J Int Med Res 2008;36(6):1220-1226. 2012;34(4):459-467. View abstract. Nutritional and metabolic roles of intestinal flora. Effect of thiamine supplementation in critically ill patients: A systematic review and meta-analysis. Nord Psykiatr Tidsskr 1989;43:291-294. View abstract. Sica, D. A. Loop diuretic therapy, thiamine balance, and heart failure. Ulusakarya A, Vantelon JM, Munck JN, et al. Somogyi JC, Nageli U. Antithiamine effect of coffee. N.Engl J Med 8-26-1976;295(9):461-467. View abstract. View abstract. Am.J.Obstet.Gynecol. Clin Pharmacol Ther 1960;1:483-524. Cochrane Database.Syst.Rev 2001;(2):CD001498. View abstract. MOROZ, R. and RECHTER, E. MANAGEMENT OF PATIENTS WITH IMPENDING AND FULL-BLOWN DELIRIUM TREMENS. View abstract. View abstract. JAMA 7-9-1997;278(2):144-151. View abstract. What is Thiamine Mononitrate: Uses, Warnings & Interactions A. and Byrne, E. The therapy of respiratory chain encephalomyopathy: a critical review of the past and current perspective. View abstract. View abstract. View abstract.

de, Lonlay P., Fenneteau, O., Touati, G., Mignot, C., Billette, de, V, Rabier, D., Blanche, S., Ogier de, Baulny H., and Saudubray, J. M. [Hematologic manifestations of inborn errors of metabolism]. A randomized double-blind placebo-controlled trial of intravenous thiamine for prevention of delirium following allogeneic hematopoietic stem cell transplantation. Balldin, J. and Bokstrom, K. Treatment of alcohol abstinence symptoms with the alpha 2-agonist clonidine. Alcohol Clin Exp Res 1989;13(1):95-98. Psychopharmacol.Bull 1975;11(1):24-27. Simpson, R. K., Fitz, E., Scott, B., and Walker, L. Delirium tremens: a preventable iatrogenic and environmental phenomenon. View abstract. Funderburk, F. R., Allen, R. P., and Wagman, A. M. Residual effects of ethanol and chlordiazepoxide treatments for alcohol withdrawal. Eat.Weight.Disord. Join the ODS Email List. J Am Diet Assoc 1998;98:699-706. View abstract. Singleton, C. K. and Martin, P. R. Molecular mechanisms of thiamine utilization. Hosp Pract (1995) 2022;50(1):27-36. Ives AR, Paskewitz SM. A review. Levy WC, Soine LA, Huth MM, Fishbein DP. Thiamine Mononitrate: Benefits, Side Effects, Best Time to - SuppleWiki They can tell you if the dietary supplements might interact with your medicines or if the medicines might interfere with how your body absorbs, uses, or breaks down nutrients such as thiamin. Here are some examples of what this research has shown. Cumming RG, Mitchell P, Smith W. Diet and cataract: the Blue Mountains Eye Study. 1970;22(2):181-182. Chemical stability and reaction kinetics of thiamine mononitrate in the Vitamin B1 (Thiamine) Information | Mount Sinai - New York Amsterdam, the Netherlands: Exerpta Medica;1976. Smidt LJ, Cremin FM, Grivetti LE, Clifford AJ. Thiamine is a prescription and over-the-counter ( OTC) vitamin, also called vitamin B1. However, certain groups of people are more likely than others to have trouble getting enough thiamin: Talk with your health care provider(s) about thiamin and other dietary supplements to help you determine which, if any, might be valuable for you. Arch Gen Psychiatry 1983;40(6):613-619. J Neurosurg. Ann Intern Med 1976;85(6):765-768.

Valerio, G., Franzese, A., Poggi, V., and Tenore, A. View abstract. Thiamine supplementation in hospitalized patients with altered mental status: does it help?. Lake Zurich, IL: Fresenius Kabi, LLC; September 2019. Meador, K., Loring, D., Nichols, M., Zamrini, E., Rivner, M., Posas, H., Thompson, E., and Moore, E. Preliminary findings of high-dose thiamine in dementia of Alzheimer's type. Alston TA.

Wooley, J. Hernandez BY, McDuffie K, Wilkens LR, et al. WKS is often associated with the overuse of alcohol ( 24 ). Acta Psychiatr.Scand 1978;58(2):174-190. Am J Clin Nutr 1997;66:925-8. Contact Dermatitis.

Bergmann, A. K., Sahai, I., Falcone, J. F., Fleming, J., Bagg, A., Borgna-Pignati, C., Casey, R., Fabris, L., Hexner, E., Mathews, L., Ribeiro, M. L., Wierenga, K. J., and Neufeld, E. J. Thiamine-responsive megaloblastic anemia: identification of novel compound heterozygotes and mutation update. Park JE, Shin TG, Jo IJ, et al. Hilker DM, Somogyi JC. 2019;19(1):96. Thiamine for preventing dementia development among patients with alcohol use disorder: A nationwide population-based cohort study. View abstract. Proctor, M. L. and Murphy, P. A. Herbal and dietary therapies for primary and secondary dysmenorrhoea. Taking thiamine by mouth helps correct certain inherited metabolic disorders, including Leigh's disease, maple syrup urine disease, and others. 1973;29(2):78-81. 2012;148(4):511-522. Thiamine nitrate | C12H17N5O4S | CID 10762 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities . Neurology 1982;32(11):1239-1246. Barel AO, Delune M, Clarys P, and Gabard B. These B vitamins, often referred to as B-complex vitamins, also help the body metabolize fats and protein. View abstract. Gillman, M. A. and Lichtigfeld, F. J. (letter) South Med J 2003;96:114-5. health professional fact sheet on Thiamin. B., Girard, D. E., and Cooney, T. G. Current concepts. Am J Psychiatry 1961;118:323-327. Bautista-Hernandez, V. M., Lopez-Ascencio, R., Del Toro-Equihua, M., and Vasquez, C. Effect of thiamine pyrophosphate on levels of serum lactate, maximum oxygen consumption and heart rate in athletes performing aerobic activity. View abstract. Diabetes Obes.Metab 2007;9(3):233-245. View abstract. Constant, J. View abstract. View abstract. Annu.Rev Biochem 2009;78:569-603. View abstract. Lichtigfeld, F. J. and Gillman, M. A. Analgesic nitrous oxide for alcohol withdrawal is better than placebo. Combination therapy of vitamin C and thiamine for septic shock: a multi-centre, double-blinded randomized, controlled study. J Int Med Res 1979;7(3):168-173. Both are heat labile, 60 and also sensitive to humidity, oxygen exposure, the presence of sulfites, and radiation. VP-VITE RX- ascorbic acid, thiamine mononitrate, riboflavin, niacinamide, pyridoxine hydrochloride, folic acid, cyanocobalamin, biotin, and calcium pantothenate tablet If this SPL contains inactivated NDCs listed by the FDA initiated compliance action, they will be specified as such. View abstract. Previous Next . A pilot study of thiamin and folic acid in hemodialysis patients with cognitive impairment. Alcohol Alcohol 1989;24(2):109-112. View abstract. Thornalley, P. J. Arch Intern Med 1987;147(7):1223-1226. Kanchanasurakit S, Suthumpoung P, Santimaleeworagun W, et al. Prevention of incipient diabetic nephropathy by high-dose thiamine and benfotiamine. Some supplements use a synthetic form of thiamin called benfotiamine. vitamin B1 (thiamine) dosing, indications, interactions, adverse Am J Obstet Gynecol 1996;174:1335-8.

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