how to reduce oxidative stress in sperm28 May how to reduce oxidative stress in sperm
Waris G, Ahsan H. Reactive oxygen species: role in the development of cancer and various chronic conditions. These changes, in turn, increase tyrosine phosphorylation, that is the major driving force for capacitation (54). Aitken, R. J. Agarwal, A. Gastroenterology 134, 16411654 (2008). Aitken R, Vernet P. Maturation of redox regulatory mechanisms in the epididymis. Also, as a result of capacitation, acrosome membrane becomes unstable, then several hydrolytic enzymes like acrosin are released during acrosomal reaction and allowing sperm to binds oocyte (55, 56). J. Urol. The presence of a truncated base excision repair pathway in human spermatozoa that is mediated by OGG1. Sci. 43, 1008310101 (2015). This is a preview of subscription content, access via your institution. A. Faiq, M., Dada, R., Sharma, R., Saluja, D. & Dada, T. CYP1B1: a unique gene with unique characteristics. Asian J. Androl. In fact, enhancement of ROS level in semen produced by abnormal spermatozoa can be a main cause of sub-fertility and even infertility. Conclusion: OS is an important cause of male factor infertility. Nat. & Clarkson, J. S. Cellular basis of defective sperm function and its association with the genesis of reactive oxygen species by human spermatozoa. Mol. Eskiocak S, Gozen AS, Kilic AS, Molla S. Association between mental stress & some antioxidant enzymes of seminal plasma. Longev. Havrylyuk, A., Chopyak, V., Boyko, Y., Kril, I. De Rosa et al, indicated that NO and lead can diminish the seminal quality, and motor vehicles by releasing NO, have a negative effect on male fertility (111). Agarwal A, Prabakaran SA. Cell Sci. Aitken, R. J., Smith, T. B., Jobling, M. S., Baker, M. A. Natl Acad. Pract. Oxidative stress is the result of imbalance between the reactive oxygen species (ROS) and antioxidants in the body which can lead to sperm damage, deformity, and eventually male infertility. Thannickal, V. J. 7, 401411 (2007). Aitken RJ. 24, 281291 (2003). Steril. Normally, these excessive cytoplasms are omitted by Sertoli cells during spermiogenesis (29, 30). FOIA Eur. Bucak MN, Ateahin A, Varl , Yce A, Tekin N, Akay A. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). CAS Endocrinol. Internet Explorer). Careers, Unable to load your collection due to an error. Kumar, S. B., Yadav, R., Yadav, R. K., Tolahunase, M. & Dada, R. Telomerase activity and cellular aging might be positively modified by a yoga-based lifestyle intervention. However, oxidative stress which is related to hyperglycemia is due to over generation of superoxide in mitochondria (93, 94). Momeni HR, Soleimani Mehranjani M, Abnosi MH, Mahmoodi M. Effects of vitamin E on sperm parameters and reproductive hormones in developing rats treated with para-nonylphenol. PLoS ONE 8, e68490 (2013). You are using a browser version with limited support for CSS. Longev. Reprod. J Transl Med. & Darzynkiewicz, Z. & Aitken, R. J. Reactive oxygen species in spermatozoa: methods for monitoring and significance for the origins of genetic disease and infertility. 16, 6678 (2012). Physiol. Open Access Whilst physiological levels of ROS are vital for optimal sperm function; when present in exaggerated levels, ROS may have detrimental effects on sperm quality and function, and ultimately result in infertility. Dinesh, V., Shamsi, M. & Dada, R. Supraphysiological free radical levels and their pathogenesis in male infertility. Reprod. Agbaje et al stated that, the level of sperm DNA fragmentation in diabetic men is higher than normal men (95). Aliabadi E, Mehranjani MS, Borzoei Z, Talaei-Khozani T, Mirkhani H, Tabesh H. Effects of L-carnitine and L-acetyl-carnitine on testicular sperm motility and chromatin quality. Free radicals and antioxidants in normal physiological functions and human disease. 1, 4047 (2000). Although, there is a long list of intrinsic and extrinsic factors which can induce oxidative stress, but the main generally accepted etiologies are the followings: Several studies have shown that alcohol consumption, can increase the abnormalities in nucleous and plasma membrane of spermatozoa (59, 60). Decline of semen quality and increase of leukocytes with cigarette smoking in infertile men. Fanaei H, Khayat S, Halvaei I, Ramezani V, Azizi Y, Kasaeian A, et al. Kong, A. et al. In addition, it can decrease the antioxidants level , for example: vitamine E, vitamine C and increase in ROS level of seminal plasma (61, 68-71). Li, Y.-J. Sanocka D, Kurpisz M. Reactive oxygen species and sperm cells. Urdinguio, R. G. et al. Biomarkers of exposure to vitamins A, C, and E and their relation to lipid and protein oxidation markers. Ther. Development of an image analysis system to monitor the retention of residual cytoplasm by human spermatozoa: correlation with biochemical markers of the cytoplasmic space, oxidative stress, and sperm function. When stimulated by FSH, the Sertoli cell initiates spermatogenesis. The Impact of Antioxidants and Oxidative Stress on Sperm Quality Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y, et al. When there is an imbalance of reactive . Everything You Should Know About Oxidative Stress - Healthline Evans, M. D., Dizdaroglu, M. & Cooke, M. S. Oxidative DNA damage and disease: induction, repair and significance. Imhof M, Lackner J, Lipovac M, Chedraui P, Riedl C. Micronutrient supplementation increases sperm quality in the sub-fertile male. 274, 1206112066 (1999). Mazilli et al demonstrated that, in patients with sperm culture-positive for aerobic bacteria, the superoxide anion production was high (120). Despite the efforts of the male genital tract to treat this problem Moretti E, Signorini C, Corsaro R, Giamalidi M, Collodel G. Antioxidants (Basel). All treatments or procedures that include the in vitro handling of both human oocytes and sperm or of embryos for the purpose of establishing a pregnancy. Klose, R. J. 79, 292300 (2003). Nucleic Acid Res. Effects on the motility of intact spermatozoa and on sperm axonemes. Any substance that prevents or reduces damage caused by free-radicals (highly reactive chemicals containing oxygen) that attack other molecules and modify their chemical structure. Genet. It has shown that activated leukocytes in response to different inducers like infection and inflammation can produce up to 100 fold higher levels of ROS compared with non-activated leukocytes (8, 43). Carlson, L. E., Speca, M., Patel, K. D. & Goodey, E. Mindfulness-based stress reduction in relation to quality of life, mood, symptoms of stress, and immune parameters in breast and prostate cancer outpatients. NO, is a lipophilic molecule and it has cytotoxic effects on adjacent sperm cells. 15, 221225 (2013). High levels of oxidative stress result in damage to sperm DNA, RNA transcripts, and telomeres and, therefore might provide a common underlying aetiology of male infertility and recurrent pregnancy loss, in addition to congenital malformations, complex neuropsychiatric disorders, and childhood cancers in children fathered by men with defective sperm cells. Prog. Bhasin, M. K. et al. Gonzales G, Munoz G, Sanchez R, Henkel R, Gallegos-Avila G, Daz-Gutierrez O, et al. Richardson, L. L., Pedigo, C. & Handel, M. A. Indian J. Med. Sun JG, Jurisicova A, Casper RF. Int. 18 July 2022, Cell & Bioscience 23, 17251731 (2012). Schaur, R. J. Studies have shown that ROS generation in cytoplasmic droplets is mediated by cytosolic enzyme, called glucose-6-phosphate dehydrogenase (G6PD), which induces high levels of ROS production during two pathways, I) nicotinamid adenine dinucleotide phosphate (NADPH) located in sperm plasma membrane and II) NADPH- dependent oxido-reductase known as diphorase located in middle piece at mitochondrial respiratory level (33-37). Male infertility testing: reactive oxygen species and antioxidant capacity. Does garlic help improve sperm motility? Before Int. The authors declare no competing financial interests. 49, 8394 (2003). Shannon, P. & Curson, B. Kinetics of the aromatic l-amino acid oxidase from dead bovine spermatozoa and the effect of catalase on fertility of diluted bovine semen stored at 5 C and ambient temperatures. J. Androl. Biomed. Google Scholar. Treatment usually involves antioxidant supplementation and, when possible, elimination of the causative factor. -, Agarwal A, Saleh RA, Bedaiwy MA. These antioxidants are divided to enzymatic and non-enzymatic antioxidant and male reproductive system has both antioxidant (1). Diabetes mellitus and sperm parameters. Andrologia 40, 209218 (2008). Innes, K. E., Bourguignon, C. & Taylor, A. G. Risk indices associated with the insulin resistance syndrome, cardiovascular disease, and possible protection with yoga: a systematic review. Eskiocak S, Gozen A, Taskiran A, Kilic A, Eskiocak M, Gulen S. Effect of psychological stress on the L-arginine-nitric oxide pathway and semen quality. Google Scholar. eCollection 2019. Aitken and his group were the pioneers of research and study in the field of physiological role of ROS, in male reproductive system (47). & Arakawa, H. Identification of ALDH4 as a p53-inducible gene and its protective role in cellular stresses. Bisht, S., Faiq, M., Tolahunase, M. et al. Ann. These factors have a direct effect on sperm quality. Reprod. Protective effect of vitamin E and selenium combination on deltamethrin-induced reproductive toxicity in male rats. Free radical theory of aging: implications in male infertility. Wang A, Fanning L, Anderson D, Loughlin K. Generation of reactive oxygen species by leukocytes and sperm following exposure to urogenital tract infection. de Souza-Pinto, N. C., Hogue, B. Gomez E, Buckingham DW, Brindle J, Lanzafame F, Irvine DS, Aitken RJ. Mutat. Systematic review of antioxidant types and doses in male infertility: Benefits on semen parameters, advanced sperm function, assisted reproduction and live-birth rate. Murrell, A. et al. It is generally accepted that antioxidant therapy can improve the sperm quality and male fertility by reducing oxidative stresses. Arch Gynecol Obstet. Reprod. Oxidative Stress: Definition, Effects on the Body, and Prevention What is oxidative stress, and why does it matter? Br. Sellami, A. et al. Arab J Urol. Reprod. Frederiks WM, Vreeling-Sindelrov H. Localization of glucose-6-phosphate dehydrogenase activity on ribosomes of granular endoplasmic reticulum, in peroxisomes and peripheral cytoplasm of rat liver parenchymal cells. Epigenetic reprogramming of the male genome during gametogenesis and in the zygote. Keskes-Ammar, L. et al. Exploring co-genotoxicity of chemicals using traditional experimental methods and microarray systems. Nat. & Kurpisz, M. Cytokines in the blood and semen of infertile patients. Vitamin E (antioxidant) may . et al. Biol. Jacobsen, R. et al. Shamsi, M., Dada, R. & Dinesh, V. Supraphysiological free radical levels and their pathogenesis in male infertility. To obtain The .gov means its official. 14, 132141 (1993). 27, 414420 (2006). A free radical refers to a molecule that has at least one unpaired electron,3,4 which is responsible for the molecule's short-lived high energy state that causes instability and extreme reactivity.5 These free radicals will take part in propagative chain reactions and generate even more free radicals until two such radicals react and the . Androl. Treatment by vitamin E for 6 months can reduce the lipid peroxidation of spermatozoa and may increase the pregnancy rate in asthenozoospermic cases (151). J. Obstet. J. Urol. Two studies have examined the impact of vitamin E monotherapy on sperm . Oxidative stress and male infertility | Nature Reviews Urology Ascorbic acid protects against endogenous oxidative DNA damage in human sperm. A process that sperm undergo as they travel through the woman's reproductive tract. It is shown that Pb can decrease sperm normal morphology, count and viability (112). Best practice policies for male infertility. Free Radic. Oxidative stress is an imbalance of free radicals and antioxidants in the body, which can lead to cell and tissue damage. MacLeod, J. Oxygen is important for aerobic metabolism of spermatogenic cells, but this molecule may have detrimental effects on cells via production of ROS. Oxygen-derived species: their relation to human disease and environmental stress. Treatment by vitamin E for 6 months can reduce the lipid peroxidation of spermatozoa and may increase the pregnancy rate in asthenozoospermic cases . Antioxidants help protect the sperm from oxidative stress, which can cause damage to the DNA and affect the quality of the sperm. & Ansari, M. Can melatonin act as an antioxidant in hydrogen peroxide-induced oxidative stress model in human peripheral blood mononuclear cells? Greco E, Iacobelli M, Rienzi L, Ubaldi F, Ferrero S, Tesarik J. Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis. Mazzilli, F. et al. official website and that any information you provide is encrypted Semen characteristics and sperm morphological studies of the West African Dwarf Buck treated with Aloe vera gel extract. Reactive oxygen species represent a broad category of molecules including: a) Oxygen free radicals, such as superoxide anion (O2), hydroxyl radical (OH) and hyperoxyl radical (HOO). 2014, 426951 (2014). Steger, K. et al. & Pummer, K. The impact of cigarette smoking on human semen parameters and hormones. Omu A, Al-Azemi M, Kehinde E, Anim J, Oriowo M, Mathew T. Indications of the mechanisms involved in improved sperm parameters by zinc therapy. Dorland's Illustrated Medical Dictionary 32nd edn (Elsevier Health Sciences, 2011). volume14,pages 470485 (2017)Cite this article, Male infertility is a complex lifestyle-related disorder, Oxidative stress has adverse effects on the structural and functional integrity of sperm and is a major cause of defective sperm function and male infertility, Oxidative stress causes damage to both mitochondrial and nuclear DNA and also affects the sperm epigenome, resulting in infertility, recurrent pregnancy loss, poor pregnancy outcomes and an increased disease burden in the offspring, Spermatozoa are most vulnerable to oxidative stress and oxidative DNA damage (ODD) as these cells have limited antioxidant defence mechanisms and a limited capacity for detection and repair of DNA damage, A number of intrinsic and extrinsic factors can regulate oxidative stress, and these must be maintained at moderate levels for optimal sperm function and the maintenance of cellular homeostasis and redox-sensitive signal-transduction pathways, Simple lifestyle modifications and interventions can substantially reduce levels of testicular inflammation, oxidative stress and ODD and improve the quality of life of infertile couples. Aitken, R. J., Buckingham, D. W. & West, K. M. Reactive oxygen species and human spermatozoa: analysis of the cellular mechanisms involved in luminol- and lucigenin-dependent chemiluminescence. In a variety of human infectious, ROS, are produced generally by viruses besides bacteria and parasites (124).
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